Hormonal high raises cancer risk

 作者:公乘柒也     |      日期:2019-03-08 05:09:00
By Michael Day WOMEN with high levels of the sex hormones oestradiol and testosterone seem to be at greater risk of breast cancer. This may allow doctors to identify women at high risk with a simple test and offer preventative treatment. Earlier research suggested sex hormones play a role in causing breast cancer. A team led by Jane Cauley at the University of Pittsburgh in Pennsylvania investigated the link by studying 97 women with breast cancer and 244 controls. All were aged 65 years or older. They divided the women into four groups according to the average levels of oestradiol and testosterone in their blood. Those in the group with highest levels of oestradiol and testosterone were respectively 3.6 and 3.3 times more likely to have breast cancer than those in the group with the lowest hormone levels (Annals of Internal Medicine, vol 130, p 270). Other risk factors, such as family history of breast cancer, were similar in both groups. “This type of information could help clinicians direct high-risk women to consider chemoprevention for breast cancer,” says Cauley. However, she says the extremely sensitive assays needed to test hormone levels in older women are not yet routinely available. Janet Dunn of the Cancer Research Campaign in London is intrigued. However, she notes that the study doesn’t rule out the possibility that higher hormone levels result from the cancer,